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  • Title: Transcription of class II MHC gene by interferon-gamma in FRTL-5 cells.
    Author: Lee MS, Lee JO, Kang TW, Lee JH.
    Journal: J Korean Med Sci; 1992 Sep; 7(3):189-92. PubMed ID: 1285917.
    Abstract:
    The intracellular mechanism by which interferon-gamma induces the expression of class II major histocompatibility complex (MHC) antigen in nonlymphoid cells is not clear. The effect of recombinant rat interferon-gamma (IFN-gamma), and cycloheximide on the expression of class II MHC gene was studied using the techniques of immunocytochemical staining and northern blot analysis. IFN-gamma induced de novo transcription of class II MHC gene and class II MHC antigen expression on the cell surface. Cycloheximide did not inhibit IFN-gamma-induced class II MHC antigen expression in a dose-dependent manner indicating translational blockade. These results suggest that IFN-gamma induces class II MHC antigen expression via de novo transcription of class II MHC gene leading to synthesis of new class II MHC molecule.
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