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  • Title: A water-soluble azobenzene cross-linker for photocontrol of peptide conformation.
    Author: Zhang Z, Burns DC, Kumita JR, Smart OS, Woolley GA.
    Journal: Bioconjug Chem; 2003; 14(4):824-9. PubMed ID: 12862437.
    Abstract:
    We have designed and synthesized a water-soluble, sulfonated version of an azobenzene-based thiol-reactive cross-linker that can be introduced into peptides and proteins and act as a conformational photoswitch. The sulfonated compound is shown to effect a similar degree of conformational control on a model peptide helix system, as its nonsulfonated counterpart but can be introduced without the need for any organic cosolvent. The sulfonated azobenzene cross-linker thus expands the range of proteins to which photocontrol can be applied.
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