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  • Title: Influence of new gamma-hydroxybutyric acid amide analogues on the central nervous system activity in mice.
    Author: Sałat K, Mendyk A, Librowski T, Czarnecki R, Malawska B.
    Journal: Pol J Pharmacol; 2002; 54(6):731-6. PubMed ID: 12866734.
    Abstract:
    The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. picrotoxin- and pentetrazole-induced seizures and in the thiopental-induced sleep test. The results of pharmacological in vivo experiments with the gamma-hydroxybutyric acid amide analogues presented below show that the compounds possess variable influence on the central nervous system in mice.
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