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  • Title: Association of L protein and in vitro tomato spotted wilt virus RNA-dependent RNA polymerase activity.
    Author: Chapman EJ, Hilson P, German TL.
    Journal: Intervirology; 2003; 46(3):177-81. PubMed ID: 12867756.
    Abstract:
    We have previously described an in vitro assay for RNA-dependent RNA polymerase activity in virions of tomato spotted wilt virus (TSWV). Here we report antibody inhibition of virion-associated RNA synthesis in vitro with an L-protein-specific polyclonal antibody raised against the carboxy-terminus of the L protein. In contrast, RNA synthesis was not inhibited by a heterologous antiserum and was unaffected by antiserum raised against an internal portion of the L protein. Our results directly associate the TSWV L protein, the putative viral polymerase, with RNA synthesis functions in vitro.
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