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  • Title: [Growth hormone, insulin-like growth factor and insulin-like growth factor binding protein in young type I diabetes patients with the onset of diabetic angiopathy].
    Author: Peczyńska J, Urban M, Głowińska B, Urban B.
    Journal: Pol Merkur Lekarski; 2003 Apr; 14(82):336-9. PubMed ID: 12868196.
    Abstract:
    UNLABELLED: Growth hormone, insulin-like growth factors and their binding proteins are now gaining a great interest in the development of microvascular complications in diabetic children and adolescents. THE AIM OF THE STUDY WAS: 1. Evaluation of growth hormone (GH), insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein (IGFBP-3) levels in youths with diabetes type 1. 2. Evaluation of correlations between this proteins and the development of microvascular complications and metabolic control. MATERIAL AND METHODS: The study was carried out on 39 young diabetic persons aged (8-20 yrs), mean-14.8, suffering from diabetes mean 7.45 yrs (2.3-15), 20 boys and 19 girls, diabetic outpatient clinic patients. The study group was divided into 2 groups: I, n = 11, with the begin of microangiopathy and group II, n = 28, without any symptoms of vascular complications. Control group consisted of 16 healthy adolescents. GH, IGF-1 and IGFBP-3 levels were estimated by use of radioimmunoenzymatic methods. RESULTS: In adolescents with diabetes we found higher GH levels, and lower IGF-1 as well as IGFBP-3 levels in comparison to control group. Statistically higher were IGF-1 and IGFBP-3 levels in children with diabetes duration longer than 10 years. Metabolic control did not influence GH, IGF-1 or IGFBP-3 levels. CONCLUSIONS: 1. Children and adolescents with diabetes type 1 have elevated level of growth hormone, with lower level of IGF-1 and IGFBP-3. 2. Oversecretion of growth hormone did not depend on metabolic control. 3. Adolescents with diabetic microangiopathy have significantly elevated levels of growth hormone and low levels of IGFBP-3. 4. Disturbances in axis GH-IGF-1--IGFBP-3 seems to be responsible for early development of diabetic microangiopathy. This knowledge may give new opportunities for therapy diabetic children and adolescents with early phases of microangiopathy with recombinated IGF-1.
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