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  • Title: Synthesis of DNA-peptide conjugates by solid-phase fragment condensation.
    Author: Kubo T, Morikawa M, Ohba H, Fujii M.
    Journal: Org Lett; 2003 Jul 24; 5(15):2623-6. PubMed ID: 12868874.
    Abstract:
    [reaction: see text] DNA-peptide conjugates were synthesized by condensing partially protected peptide fragments and oligonucleotides on a CPG support using diisocyanatoalkane as a linker. After cleavage and deprotection with aqueous ammonia, pure products were obtained by single RPHPLC purification in satisfactory yields and identified by a MALDI-TOF MS spectrometer. This method allows one to prepare DNA-peptide conjugates with any components and sequences of DNA and peptides.
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