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Title: Rh(I)-catalyzed direct ortho-alkenylation of aromatic ketimines with alkynes and its application to the synthesis of isoquinoline derivatives. Author: Lim SG, Lee JH, Moon CW, Hong JB, Jun CH. Journal: Org Lett; 2003 Jul 24; 5(15):2759-61. PubMed ID: 12868908. Abstract: [reaction: see text] Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.[Abstract] [Full Text] [Related] [New Search]