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  • Title: [Molecular characterization of hantavirus Shandong isolate JNL virus strain].
    Author: Yao ZH, Yu YX, Dong GM, Meng XZ, Jin ZH.
    Journal: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 2003 Jun; 17(2):112-5. PubMed ID: 12869988.
    Abstract:
    OBJECTIVE: To understand the molecular epidemiologic characteristics of hantavirus Shandong isolate JNL virus strain. METHODS: The complete M and S gene of the JNL virus isolated from Shandong Province was amplified by RT- PCR, and the purified PCR product was cloned into T vector for sequencing. RESULTS: The results revealed that the JNL M segment was 3615 bp in length, encoding 1135 amino acids, and the S segment was 1698 bp encoding 429 amino acids, JNL belongs to HTN virus. The comparison of homology with HTN and SEO types showed that the difference of M and S complete sequences between JNL and all other HTN virus strains reached 20.0%-20.6%, and 15.5%-16.0%, respectively. Phylogenetic tree also showed that the position of JNL is located at a different clade. CONCLUSIONS: HTN virus Shandong local isolate JNL strain is a new specific HTN subtype virus.
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