These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Congenital malformations and chronic diseases of the mother. Latin American Collaborative Study of Congenital Malformations (ECLAMC) 1971-1999].
    Author: Ordóñez MP, Nazer J, Aguila A, Cifuentes L.
    Journal: Rev Med Chil; 2003 Apr; 131(4):404-11. PubMed ID: 12870235.
    Abstract:
    BACKGROUND: Several maternal diseases, such as diabetes mellitus or high blood pressure, are associated with a higher risk for fetal or neonatal problems. AIM: To study the association between chronic diseases of the mother and congenital malformations. MATERIAL AND METHODS: Review of the records of the Latin American Collaborative Study of Congenital Malformations (ECLAMC) at the University of Chile Clinical Hospital. A sample of 383 mothers with a chronic disease was compared with 297 healthy mothers. The presence of congenital malformations in the newborns was studied. The odds ratio (OR) of a mother to have a child with a congenital malformation was calculated. RESULTS: Mothers with bronchial asthma, diabetes mellitus, hypertension and hypothyroidism had an OR over 1 of having a child with a congenital malformation. No association between maternal obesity and offspring malformations was observed. Offspring of diabetic mothers had 8.95 times more probabilities of having a major malformation and 4.95 times more probabilities of having a minor defect. CONCLUSIONS: Offspring of mothers with diabetes mellitus, bronchial asthma, hypertension or hypothyroidism have a higher risk of presenting a congenital malformation, when compared with offspring of healthy mothers.
    [Abstract] [Full Text] [Related] [New Search]