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  • Title: MR imaging features of thyrotropin-secreting pituitary adenomas at initial presentation.
    Author: Sarlis NJ, Gourgiotis L, Koch CA, Skarulis MC, Brucker-Davis F, Doppman JL, Oldfield EH, Patronas NJ.
    Journal: AJR Am J Roentgenol; 2003 Aug; 181(2):577-82. PubMed ID: 12876051.
    Abstract:
    OBJECTIVE: We report the MR imaging characteristics of thyrotropin-producing pituitary adenomas at their initial presentation and also report the role of MR imaging in predicting surgical outcome in these rare tumors. MATERIALS AND METHODS: We reviewed the records and MR images of 21 patients with thyrotropin-producing pituitary adenomas from 1984 to 1999. The imaging features of these tumors were examined, including enhancing characteristics and tumor volumes. A staging system of tumor invasion was designed by grading cavernous and sphenoid sinus invasion and suprasellar extension. A cumulative invasion score was then used as a predictor of short-term surgical outcome. RESULTS: Twenty patients had macroadenomas, and one patient had a microadenoma. In 17 of 21 patients, the thyrotropin-producing pituitary adenoma was clearly visualized as a hypoenhancing mass compressing the normal pituitary gland. Conversely, in four patients, the pituitary gland was not discernible because of complete distortion by the adenoma. Thyrotropin-producing pituitary adenomas were large and showed a tendency to invade surrounding structures. Tumor volume ranged from 0.42 to 94.2 cm(3) (mean +/- SD, 16.0 +/- 17.8 cm(3)). The mean score of tumor invasion was 4.77 +/- 2.06 of a maximal possible value of 9.0. A high staging score was found to be predictive of an unfavorable response to surgery. CONCLUSION: Thyrotropin-producing pituitary adenomas are usually large tumors at initial presentation with hypoenhancing features compared with normal pituitary tissue; they tend to be invasive. Greater amounts of invasion correlate with incomplete surgical removal of the tumor and continued hormonal secretion.
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