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  • Title: Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A).
    Author: Syrogiannopoulos GA, Grivea IN, Ednie LM, Bozdogan B, Katopodis GD, Beratis NG, Davies TA, Appelbaum PC.
    Journal: Antimicrob Agents Chemother; 2003 Aug; 47(8):2699-702. PubMed ID: 12878546.
    Abstract:
    Erythromycin-resistant Streptococcus pneumoniae isolates from young carriers were tested for their antimicrobial susceptibility; additionally, inducibility of macrolide and clindamycin resistance was investigated in pneumococci carrying erm(A), erm(B), or mef(A). Of 125 strains tested, 101 (81%) were multidrug resistant. Different levels of induction were observed with erythromycin, miocamycin, and clindamycin in erm(B) strains; however, in erm(A) strains only erythromycin was an inducer. Induction did not affect macrolide MICs in mef(A) strains.
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