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  • Title: Measurement of urinary porphyrins and porphyrin precursors in Dutch hospital laboratories: a review of quality control over 5 years.
    Author: Zuijderhoudt FM, Weykamp CW, Willems HL.
    Journal: Ann Clin Biochem; 2003 Jul; 40(Pt 4):417-8. PubMed ID: 12880545.
    Abstract:
    BACKGROUND: We evaluated a quality control scheme for the measurement of urinary uroporphyrin, coproporphyrin, total urinary porphyrins and precursors of urinary porphyrins, delta-aminolevulinic acid and porphobilinogen that was performed in The Netherlands during a period of 5 years. METHODS: Six quality control samples were distributed each year to the participating laboratories. Mean concentrations and the corresponding coefficients of variation were calculated. RESULTS: Coefficients of variation varied widely and were very high in the concentration ranges that can be found in patients with low-grade porphyria. CONCLUSION: Commutable calibrators are needed to improve the laboratory diagnosis of porphyria.
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