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  • Title: [Effect of negative pressure suction on rabbit optic nerve and retina].
    Author: Ye AL, Pang GX, Han YH.
    Journal: Zhonghua Yan Ke Za Zhi; 2003 Mar; 39(3):136-9. PubMed ID: 12880568.
    Abstract:
    OBJECTIVE: To study the effect of acute intraocular pressure (IOP) elevation on the optic nerve and retina in laser in situ keratomileusis (LASIK). METHODS: Acute IOP was increased to 65 mm Hg for different period of time (30 s, 1 min and 3 min) by using scleral suction on rabbit eyes. The tissues of retina and optic nerve of immediately extirpated group (instant group), of 2 weeks later extirpated group (recovery group) both after the negative pressure suction and of normal rabbit eyes were examined with electron and light microscope. RESULTS: After the negative pressure suction for 30 s, 1 min, and 3 min respectively, the optic nerve and retinal cells changed lightly; some part of optic nerve and retinal cells changed; optic nerve fibers and retinal cells changed sharply. CONCLUSION: Ultrastructural changes of retina and optic nerve may be induced by acute IOP elevation in LASIK. The longer the time, the more apparent the changes.
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