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  • Title: [The use of large doses of retabolil and support loads for prevention of osteopenia in male rats during suspension].
    Author: Durnova GN.
    Journal: Aviakosm Ekolog Med; 2003; 37(3):20-3. PubMed ID: 12882032.
    Abstract:
    The histological and histomorphometric techniques were used to evaluate effects of anabolic steroid rhetabolil and graded support loads on the osteopenia progress in suspended rats. Thirty-day head-down tail suspension was found to inhibit body mass gain, induce a moderate stress reaction, dampen the longitudinal bone growth and provoke osteopenia in the spongy metaphysis of rats' tibiae. Rhetabolil injection at a total dose of 10 mg per 100 g of the body mass (a large dose) prevented tibial osteopenia, and yet it hampered bone growth in length. Daily 3-hr. support loads also inhibited osteopenia in the suspended rats, especially when combined with the rhetabolil injections. The unfavorable side-effect of the dose was virtually complete thymus aplasia in all animals. Hence, large rhetabolil doses as a means against osteopenia in the inadequately loaded locomotor system should be given with great care and require further investigations.
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