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  • Title: [Familial susceptibility to aminoglycoside ototoxicity due to the A1555G mutation in the mitochondrial DNA].
    Author: Gallo-Terán J, Morales-Angulo C, del Castillo I, Moreno-Pelayo MA, Mazón A, Moreno F.
    Journal: Med Clin (Barc); 2003 Jul 12; 121(6):216-8. PubMed ID: 12882732.
    Abstract:
    BACKGROUND AND OBJECTIVE: The A1555G mutation in the mitochondrial genome causes sensorineural hearing loss and familial aminoglycoside ototoxicity. PATIENTS AND METHOD: Screening for the A1555G mutation was performed on 72 patients with nonsyndromic sensorineural hearing loss. RESULTS: The A1555G mutation was identified in 15 patients (20.8%). All of them presented maternal relatives with deafness. Individuals with the A1555G mutation that had been treated with aminoglycosides developed more severe hearing loss. CONCLUSIONS: The A1555G mutation should be screened in individuals with maternal relatives with hearing loss before administering aminoglycosides.
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