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  • Title: CD34-positive stromal cells in primary lung carcinomas.
    Author: Nakayama H, Enzan H, Yamamoto M, Miyazaki E, Hidaka C, Okumichi T, Okumichi A, Kajihara H.
    Journal: Oncol Rep; 2003; 10(5):1313-6. PubMed ID: 12883699.
    Abstract:
    To investigate the phenotypes of stromal cells in primary lung carcinomas, we examined the distribution of CD34-positive stromal cells in primary lung carcinomas, with special reference to histological types. In total 26 surgically resected primary lung carcinomas (13 adenocarcinomas, 10 squamous cell carcinomas, 2 large cell carcinomas, and 1 small cell carcinoma and their normal tissues were examined. CD34-positive stromal cells were observed in connective tissue adjacent to the bronchiolar and bronchial epithelium in normal lung tissues. Nine of the 13 adenocarcinomas had CD34-positive stromal cells in the tumor stroma, whereas none of the other histological type tumors examined had CD34-positive stromal cells. These results suggest that CD34-positive stromal cells are specific in the stroma of primary lung adenocarcinomas, and there is a possibility that CD34-positive stromal cells may play a supportive role in primary lung adenocarcinomas.
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