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  • Title: Mutational analysis of ras gene family in lung cancer in Thai.
    Author: Petmitr S, Wongsommart D, Chaksangchaichot P, Pakeetoot T, Sutinont P, Sirivaidyapong P, Karalak A.
    Journal: Oncol Rep; 2003; 10(5):1497-501. PubMed ID: 12883730.
    Abstract:
    H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons 57 and 62 were seen in one patient, whilst no H-ras mutation was found in these patients. Bases change in K-ras gene were G right curved arrow T transversion (62%), G right curved arrow A transition (15%) and G right curved arrow C transition (15%), whereas T right curved arrow G transversion and A right curved arrow G transition were detected in N-ras mutant gene.
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