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  • Title: Hydrogenation of cinchona alkaloids over supported Pt catalyst.
    Author: Szöllosi G, Forgó P, Bartók M.
    Journal: Chirality; 2003; 15 Suppl():S82-9. PubMed ID: 12884378.
    Abstract:
    The heterogeneous catalytic hydrogenation of two isomeric cinchona alkaloids, cinchonidine and cinchonine, was studied over Pt/Al(2)O(3) in 1N H(2)SO(4) solution under 100 bar H(2) at 25 degrees C. Cinchonidine was transformed into two diastereomeric hexahydroderivatives by hydrogenation of ring A (with N) of the quinoline moiety (yield over 95%, diastereomeric ratio 2/3), whereas hydrogenation of cinchonine resulted in the formation of three products, the major one being formed by the hydrogenation of ring B (without N) (yield 60%). The isolated hexahydroderivatives were investigated by (1)H-, (13)C-NMR, (1)H-(1)H COSY, (1)H-(13)C HetCOSY, and NOESY spectroscopy and were used as modifiers in the heterogeneous enantioselective hydrogenation of ethyl pyruvate and as catalysts in the Michael addition of ethyl 2-oxocyclopentanecarboxylate to methyl vinyl ketone.
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