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  • Title: [Autoimmune hemolytic anemia presenting during treatment of chronic hepatitis C with interferon alpha].
    Author: Rizzi R, Lucarella FP, Ruggieri GB, L'Abbate M.
    Journal: Ann Ital Med Int; 2003; 18(2):107-10. PubMed ID: 12886829.
    Abstract:
    Autoimmune hemolytic anemia has been rarely described in patients with chronic hepatitis C during interferon-alpha therapy. We report a case of Coombs-positive autoimmune hemolytic anemia, occurring 9 months after the onset of monotherapy with interferon-alpha-2b (3 million units thrice in week) for chronic hepatitis C. Interferon withdrawal and prednisone treatment induced a complete remission of hematological findings after 3 months. During a follow-up period of 30 months after cessation of interferon, hemoglobin levels stabilized about 16 g/dL, and the indirect Coombs test turned negative, while the direct Coombs test remained weakly positive; besides, serum alanine aminotransferase values were normal and hepatitis C virus-RNA remained undetectable. In our patient, clinical and laboratory findings suggested a correlation between autoimmune side effects of interferon-alpha and autoimmune hemolytic anemia.
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