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  • Title: [Cerebokrast as a corrector of postischemic phenomena in acute transient cerebral ischemia].
    Author: Bazhenova TG, Plotnikov MB, Plotnikova TM, Saratikov AS.
    Journal: Biull Eksp Biol Med; 1992 Oct; 114(10):378-80. PubMed ID: 1288692.
    Abstract:
    Acute cerebral ischemia in cats (both carotid arteries occlusion during 30 min after permanent occlusion of both vertebral arteries) was accompanied by postischemic hypoperfusion and hypo-oxygenation of the cerebral tissue. Intravenous infusion of cerebrocrast (1 micrograms.kg-1.min-1 during 60 min) prevented manifestation of the postischemic phenomena. Antihypoxic effect of cerebrocrast involved the cerebral blood flow increase, brain oxygen consumption lowering and Hb-O2-affinity decrease.
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