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  • Title: [A morphological study of rat liver cells after the administration of phenobarbital and ziksorin].
    Author: Zakharova MV, Shkurupiĭ VA.
    Journal: Biull Eksp Biol Med; 1992 Oct; 114(10):409-10. PubMed ID: 1288707.
    Abstract:
    Male Wistar rats were inducted with phenobarbital and ziksorin. The inducing effect has been shown by hepatocyte hypertrophy involving the cytoplasm and nuclei. After phenobarbital injection cytoplasmic hypertrophy was due to redistribution of the plastic material in favour of the smooth-surface endoplasmic reticulum (SER). This redistribution occurred with the decrease of the energy forming and external synthetic functions of hepatocytes. After ziksorin injection SER hyperplasia was combined with proportional hyperplasia of the whole cytoplasmic organelles of the liver cells. This points to more optimal response of hepatocytes after ziksorin induction as compared with phenobarbital. Therefore, ziksorin can be recommended for clinical practice if it is necessary to stimulate processes of reparative regeneration in the liver.
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