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  • Title: [The analysis of S gene phylogenetic tree of HBV in transmission from father to infant].
    Author: Wang SS, Li WL, Peng GF, Li MM, Xiao H, Jin HL, Zeng NH, Wang ZB, Su JX.
    Journal: Zhonghua Yi Xue Za Zhi; 2003 Mar 25; 83(6):451-4. PubMed ID: 12887754.
    Abstract:
    OBJECTIVE: To study HBV transmission from father to infants, the study was carried out. METHODS: The study contained 16 pairs of fathers who was HBV carriers, and infants whose mothers wasn't HBV carriers. The infants infected HBV in womb. The homogenous of HBV S gene were compared between fathers and infants, meanwhile HBV gene phylogenetic tree were analyzed. RESULTS: The genotype of 16 pairs fathers and infants were HBV adw. The homogenous of HBV S gene were 98% approximately 100%. The mutation of 488, 491, 494, 530, 531, 546, 581, 621 nucleotide of HBV S gene caused in 112, 113, 114, 126, 131, 143, 156 amino acid substitution. The mutation of 126 amino acid from Threonine to Alanine didn't existed in the gene bank. The sequence was difference from gene classification. CONCLUSION: The homogenous of HBV S gene of fathers and infants was very high. The HBV gene characteristic in China was difference from gene bank.
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