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  • Title: Synthesis of a nitrogen analogue of sphingomyelin as a sphingomyelinase inhibitor.
    Author: Hakogi T, Taichi M, Katsumura S.
    Journal: Org Lett; 2003 Aug 07; 5(16):2801-4. PubMed ID: 12889878.
    Abstract:
    [structure: see text] Sphingomyelin nitrogen analogue 1 was designed and synthesized as a sphingomyelinase inhibitor. The synthesis was established by continuous Hofmann rearrangement and Crutius rearrangement as key steps in constructing the 3-hydroxy-1,2-diamine structure in the backbone of 1. This analogue showed moderate inhibitory activity toward SMase isolated from B. cereus.
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