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  • Title: Cascade polycyclization: exploration of a convergent route to access various tricyclic and tetracyclic products related to sterols.
    Author: Guay B, Deslongchamps P.
    Journal: J Org Chem; 2003 Aug 08; 68(16):6140-8. PubMed ID: 12895042.
    Abstract:
    The expedient synthesis of tricyclic and tetracyclic compounds via a cascade polycyclization methodology is described. Nazarov substrates (II) containing two Michael acceptors and a cyclohexenone ester (I) underwent cycloaddition followed by intramolecular 1,4-addition to furnish, in a highly stereoselective manner, tricyclic and tetracyclic products (III). Such compounds are interesting intermediates for the synthesis of polycyclic natural and unnatural products.
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