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  • Title: Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine.
    Author: Panos A, Orrit X, Chevalley C, Kalangos A.
    Journal: Eur J Cardiothorac Surg; 2003 Aug; 24(2):325-7. PubMed ID: 12895638.
    Abstract:
    Immunologic reactions to protamine sulfate during cardiac surgery are very rare. The frequency and outcome of such adverse reactions is unclear. We report a case of lethal anaphylactic reaction to protamine that occurred in a non-diabetic patient following the uneventful replacement of the ascending aorta. We also briefly review the mechanisms of this adverse reaction and emit some considerations on the management of this situation.
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