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  • Title: Tachyplesin I as a model peptide for antiparallel beta-sheet DNA binding motif.
    Author: Yonezawa A, Sugiura Y.
    Journal: Nucleic Acids Symp Ser; 1992; (27):161-2. PubMed ID: 1289803.
    Abstract:
    In this study, we present a model compound for antiparallel beta-sheet-DNA interaction. Tachyplesin I, cationic antimicrobial peptide, interacts through contacts with the minor groove. Secondary structure of tachyplesin I, antiparallel beta-sheet constrained by two disulfide bridges and connected by beta-turn, contributes significantly to its DNA binding. The present results give valuable information for design of sequence-specific DNA binding peptide based on antiparallel beta-sheet.
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