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  • Title: Alkylation reaction of phosphorus oxyacids.
    Author: Ayukawa H, Ohuchi S, Higashiya S, Singh RK, Ishikawa M, Hata T.
    Journal: Nucleic Acids Symp Ser; 1992; (27):91-2. PubMed ID: 1289839.
    Abstract:
    Alkylation reactions of phosphorus oxyacids (i.e. phosphoric acid, phosphorous acid, hypophosphorous acid) were examined by means of several methods for the synthesis of the corresponding esters. These reactions were applied to the synthesis of oligonucleotide having phosphotriester bond or phosphonate diester bond.
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