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  • Title: Shift of zinc in serum and tissues in course of experimental acute pancreatitis.
    Author: Bojarski K, Dabrowski A, Wallner G, Maciejewski R.
    Journal: Ann Univ Mariae Curie Sklodowska Med; 2002; 57(2):74-8. PubMed ID: 12898822.
    Abstract:
    The experiment was conducted upon 200 male rats of Wistar breed, weight 250-350 g, according to Heinkel and Aho's method. Four groups of rats were separated: Z--healthy (20), K1--control (60), K2--control (60), D--experimental (60). After 6, 12, 24, 48 hours since the acute pancreatitis was induced, the rats were anesthetized again (15 after each period), thoracotomy was performed and the blood from the left chamber was taken. Then after it turned into a clot, it was centrifuged for 20 minutes at 2000 rot./min. The blood serum obtained was then frozen in -25 degrees C until it was analyzed. The whole heart and right lung were taken out from the chest. The peritoneal cavity was re-opened and the pancreas, liver and left kidney were taken out. The method of the spectrophotometry of atom absorption was applied to mark the concentration of the chosen elements in the collected material. The SP 192 Pye Unicam spectrophotometer was used. The collected data were then statistically analyzed in order to define the arithmetic average and the standard deviation in the control group as well as in the examined groups. The statistic significance was defined by the application of the t-Student test and C. Cochren-Cox's test; accepting the value p < 0.05 for which the differences were taken as statistically significant. When marking zinc concentrations in the course of acute pancreatitis, the shift of this element in tissues was observed. The fall of zinc in blood serum, pancreas, kidneys, heart and lung was observed. The zinc increase was present in the liver only. Statistically significant differences were observed in the pancreas and liver in D and K2 groups, and in blood serum and kidneys in D group at 6th and 12th hour of the experiment. Differences observed in the heart muscle and lungs were not statistically significant.
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