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  • Title: What information is needed to design effective vaccination against intracellular pathogens causing chronic disease?
    Author: Bretscher PA, Hamilton D, Ogunremi O.
    Journal: Expert Rev Vaccines; 2002 Aug; 1(2):179-92. PubMed ID: 12901557.
    Abstract:
    An appreciation of global features of immune regulation may lead to vaccination strategies effective in a genetically diverse population against a number of intracellular pathogens that cause chronic disease. Such global strategies appear more straightforward than strategies requiring a detailed knowledge of the specificity of 'protective T-cells'. Global strategies may be effective against the virus, bacteria and protozoa that respectively cause AIDS, tuberculosis and the leishmaniases.
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