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  • Title: [The anti-HIV activity of beta-glycyrrhizic acid].
    Author: Pliasunova OA, Egoricheva IN, Fediuk NV, Pokrovskiĭ AG, Baltina LA, Murinov IuI, Tolstikov GA.
    Journal: Vopr Virusol; 1992; 37(5-6):235-8. PubMed ID: 1290221.
    Abstract:
    The anti-HIV activity of beta-glycyrrhizic acid (GA) and various derivatives was studied using various strains of HIV-1 and HIV-2 in primary infected lymphoblastoid cells MT-4 and monocyte cell line U-973 chronically infected with HIV-1 and containing provirus (GKV 4005). Beta-glycyrrhizic acid and its derivatives were shown to effectively inhibit HIV-1 reproduction in MT-4 cells. The antiviral effect of beta-GA sodium salt exceeded that of AZT in cells GKV 4005. The selective indices for some GA salts were evaluated, namely: 53 for 1NH4 salt of GA, 6.7 for 1K-2Li salt of GA; 4.45 for GA. The mechanism of GA action is discussed.
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