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  • Title: Synthesis of carbocyclic nucleosides and their SAH hydrolase inhibitory activities.
    Author: Kitade Y, Kozaki A, Miwa T, Nakanishi M, Yatome C.
    Journal: Nucleic Acids Symp Ser; 2000; (44):111-2. PubMed ID: 12903293.
    Abstract:
    The cellular enzyme S-adenosyl-L-homocysteine (SAH) hydrolase has emerged as a target enzyme for the molecular design of anti-viral agents. Recently, SAH hydrolase has been considered as an attractive target in parasite chemotherapy for malaria. We report synthesis of several carbocyclic purine nucleosides and their inhibitory activities against human and malaria recombinant SAH hydrolases.
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