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  • Title: [Association of HLA-DRB genes with Vogt-Koyanagi-Harada syndrome in a Chinese Han population].
    Author: Zhang M, Qiu C, Hu T.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2000 Feb; 22(1):36-40. PubMed ID: 12903490.
    Abstract:
    OBJECTIVE: To investigate the molecular genetic background of VKH syndrome in Han Chinese by HLA-DRB genotyping. METHODS: HLA-DRB genotyping was performed by PCR-SSOP method, then DR4 alleles were analyzed by SSOP and RFLP methods. RESULTS: The frequency of DRB1 * 0405 was significantly higher in VKH patients than that in normal controls (80.4% vs 8.1%, Pc < 10(-7), RR = 46.7), so was the frequency of DRB1 * 15 in DRB1 * 0405 negative individuals (Pc < 0.05, RR = 6.0). On the other hand, the frequencies of DRB1 * 14 and DRB1 * 08 were significantly lower in VKH patients than that in normal controls. Comparing the clinical features between DRB1 * 0405 positive and negative VKH patients, no significant differences were found. CONCLUSIONS: (1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to VKH syndrome, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.
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