These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A highly efficient three-component coupling of aldehyde, alkyne, and amines via C-H activation catalyzed by gold in water.
    Author: Wei C, Li CJ.
    Journal: J Am Chem Soc; 2003 Aug 13; 125(32):9584-5. PubMed ID: 12904013.
    Abstract:
    A highly efficient three-component-coupling of aldehyde, alkyne, and amine (A3 Coupling) catalyzed by gold via C-H activation was developed in water. The reaction is general, and nearly quantitative yields of the corresponding propargylamines were obtained in most cases. Both aromatic and aliphatic aldehydes and amines can be used for the reaction. No additional cocatalyst or activator is required. A mechanistic rationale for the reaction has been proposed.
    [Abstract] [Full Text] [Related] [New Search]