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  • Title: [An observation of taurine transport alterations in calcification of myocardial cells in vitro].
    Author: Shi YR, Wang SH, Bu DF, Qi YF, Gao L, Pang YZ, Tang CS.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2002 Aug; 24(4):359-63. PubMed ID: 12905652.
    Abstract:
    OBJECTIVE: To observe the alterations of taurine transport, taurine transporter (TAUT) and cysteine sulfinate decarboxylase (CSD) mRNA in the calcification of myocardial cells in vitro. METHODS: 3H-taurine measured the amount of taurine uptake. TAUT and CSD mRNA consents were measured using competitive quantitative RT-PCR in cultured and calcified myocardial cells. RESULTS: In calcification of myocardial cells, taurine concentration was decreased by 27% (P < 0.05), taurine uptake was markedly reduced, Vmax reduced by 39% (P < 0.01), there were no statistical significance of Km values between the two groups. TAUT mRNA decreased by 45% (P < 0.01), but CSD mRNA increased by 25% (P < 0.05). CONCLUSIONS: The data suggest that there were impediment of taurine transport in calcification of myocardial cells, as TAUT mRNA level was decreased, but CSD mRNA concentration was improved.
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