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  • Title: [Clinical value of induced sputum test in monitoring airway inflammation in asthma].
    Author: Zhang HB, Lin YG, Zhao XM.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2001 Oct; 23(5):432-4. PubMed ID: 12905856.
    Abstract:
    OBJECTIVE: To explore the clinical value of induced sputum test in monitoring airway inflammation in asthmatic patients. METHODS: The induced sputum test was done in 12 normal subjects and 21 asthmatic subjects; The levels of interleukin-8 (IL-8), eosinophil cation protein (ECP), malondialdehyde (MDA) in plasma and induced sputum in all subjects were measured. RESULTS: The levels of IL-8, ECP, MDA in plasma and induced sputum in unstable asthmatic patients were significantly higher than those in stable asthmatic (P < 0.01), in which the levels of IL-8, ECP, MDA in both plasma and induced sputum were significantly higher than those in normal subjects(P < 0.05); In all asthmatic patients, the levels of IL-8, ECP, MDA in induced sputum were significantly higher than those in plasma. CONCLUSION: The levels of IL-8, ECP, MDA in induced sputum could be used for monitoring airway inflammation in asthmatic patients.
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