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  • Title: [Effects of SDF-1 alpha and its receptor on regulation of hematopoiesis].
    Author: Fu JX, Zhang XG.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2001 Apr; 23(2):184-8. PubMed ID: 12905900.
    Abstract:
    Hematopoietic stem/progenitor cell transplantation is one of main choices for treating patients with malignant tumor or heredity diseases in recently year. The homing of hematopoietic stem cells(HSC) is a committed step to ensure the bone marrow hematopoiesis reconstitution. Recent studies have showed that stromal cell derived factor-1 (SDF-1) and its receptor has important effects on proliferation, differentiation, homing of HSC to bone marrow and hematopoiesis reconstitution. The purpose of this review is to give a recent update informations on mechanism of hematopoiesis regulation mediated by SDF-1 and its receptor.
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