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  • Title: [Portal vein thrombosis associated with factor V Leiden mutation in a woman who underwent exchange transfusion at birth].
    Author: Tchuenbou J, Bacq Y, Fimbel B, Metman EH.
    Journal: Gastroenterol Clin Biol; 2003 Jun; 27(6-7):645-7. PubMed ID: 12910230.
    Abstract:
    We report the case of a 18-year-old woman with portal vein thrombosis and chronic hepatitis C virus. Portal vein thrombosis was diagnosed by chance on ultrasound examination during initial hepatitis C virus-positive patient screening. The patient interview revealed a history including exchange transfusion at birth, followed by necrotising ulcerocolitis and septicemia. The investigation of general factors favoring thrombosis showed acquired protein S deficiency and heterozygous factor V Leiden mutation. This case demonstrates the value of systematic investigations for general thrombophilic factors in cases of portal vein thrombosis even when a local cause is found.
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