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  • Title: [The variation of Caspase3 activity in tanshinone induced NB4 cells apoptosis].
    Author: Liang X, Yang Y, Deng C, Meng W, Liu T, Jia Y, Cheng Y, Li L.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2003 Jul; 34(3):549-51. PubMed ID: 12910718.
    Abstract:
    OBJECTIVE: To study the variation and role of Caspase3 activity in the process of Tanshinone (Tan II A) induced NB4 cells apoptosis. METHODS: NB4 cell apoptosis induced by Tan II A was demonstrated by cell morphology, DNA content analysis and DNA fragmentation assay. Caspase3 activity was determined by spectrofluorometry, and its inhibitory assay was performed using N-acetyl-Asp-Glu-Val-Asp-aldehyde(AC-DEVD-CHO). RESULTS: Tan II A could induce NB4 cell apoptosis accompanied with increase of caspase3 activity. The induction of NB4 cell apoptosis by use of Tan II A could be partially inhibited by AC-DEVD-CHO. CONCLUSION: The induction of NB4 cell apoptosis by Tan II A could be fulfilled by activating Caspase3.
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