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  • Title: Chemical synthesis, growth-promoting activity, and metabolism of all-trans retinyl beta-glucose in the rat.
    Author: Barua AB, Olson JA.
    Journal: Int J Vitam Nutr Res; 1992; 62(4):298-302. PubMed ID: 1291531.
    Abstract:
    Reaction of all-trans retinol with alpha-D-glucopyranosyl bromide tetrabenzoate in the presence of silver carbonate gave all-trans retinyl beta-glucose in good yield. Depending on the mode of administration, retinyl beta-glucose, which is soluble in water, showed 67-100% of the growth-promoting activity of retinyl acetate in vitamin A-deficient rats. In metabolic studies on vitamin A-deficient rats, retinyl beta-glucose was rapidly hydrolyzed to retinol. The possible therapeutic uses of retinyl glucose are discussed.
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