These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of novel 1H-pyrrolizine-5-carboxamides and their antimicrobial properties.
    Author: Barsoum FF, Nawar NN.
    Journal: Boll Chim Farm; 2003 May; 142(4):160-6. PubMed ID: 12918225.
    Abstract:
    A variety of N-aryl-7-cyano-2,3-dihydro-1H-pyrrolizine-5-carboxamides 6, 8-11 were synthesized through the reaction of the 2-amino derivatives 3 with acid chlorides, aromatic and aliphatic aldehydes. In addition, 3 could directly obtained through the reaction of 2-pyrrolidinylidenepropanedinitrile (1) with chloroacetanilides 2a,b. However, reaction of 1 with-chloropropionanilide 2c gave the open-chain compound 5. The antimicrobial properties of the newly prepared compounds were screened against a variety of Gram positive, Gram-negative bacteria and yeast. Some of the prepared compounds (8a, 8c and 9a) show moderate activity against the tested Gram-positive bacteria (Staphylococcus aureus and/or Coagulase negative Staphylococcus). In addition, other compounds (6a, 9d and 9e) exhibit slight (weak) activity against Coagulase negative Staphylococcus.
    [Abstract] [Full Text] [Related] [New Search]