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  • Title: A deoxyribozyme-based molecular automaton.
    Author: Stojanovic MN, Stefanovic D.
    Journal: Nat Biotechnol; 2003 Sep; 21(9):1069-74. PubMed ID: 12923549.
    Abstract:
    We describe a molecular automaton, called MAYA, which encodes a version of the game of tic-tac-toe and interactively competes against a human opponent. The automaton is a Boolean network of deoxyribozymes that incorporates 23 molecular-scale logic gates and one constitutively active deoxyribozyme arrayed in nine wells (3x3) corresponding to the game board. To make a move, MAYA carries out an analysis of the input oligonucleotide keyed to a particular move by the human opponent and indicates a move by fluorescence signaling in a response well. The cycle of human player input and automaton response continues until there is a draw or a victory for the automaton. The automaton cannot be defeated because it implements a perfect strategy.
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