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  • Title: Enantioselective synthesis of (S)-2-amino-4-phenylbutanoic acid by the hydantoinase method.
    Author: Lo HH, Kao CH, Lee DS, Yang TK, Hsu WH.
    Journal: Chirality; 2003 Oct; 15(8):699-702. PubMed ID: 12923807.
    Abstract:
    Biosynthesis of (S)-(+)-2-amino-4-phenylbutanoic acid (1) was performed by nonenantioselective hydantoinase and L-N-carbamoylase using racemic 5-[2-phenylethyl]-imidazolidine-2,4-dione (rac-2) as a substrate. The compounds involved in this biocatalysis process could be simultaneously resolved by high-performance liquid chromatography using Chirobiotic T column with a mobile phase of EtOH/H(2)O = 10/90 at pH 4.2-4.5. To our knowledge, this is the first report of the successful production of 1 by the combination of recombinant hydantoinase and L-N-carbamoylase.
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