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  • Title: [Antibody formation to morphine and neuromediators in morphinized rats].
    Author: Tronnikov SI, Gamaleia NB, Veretinskaia AG, Borisova EV, Sudakov SK, Anokhina IP.
    Journal: Biull Eksp Biol Med; 1992 Dec; 114(12):624-6. PubMed ID: 1292693.
    Abstract:
    The paper demonstrates induction of antibodies to morphine and neurotransmitters (dopamine, norepinephrine, serotonin) in rats treated with intraperitoneal injections of morphine hydrochloride during 2 and 4 weeks in increasing doses. A contribution of such antibodies to the mechanisms of morphine tolerance and formation of physical dependence is considered.
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