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  • Title: [The immunostimulating properties of cholecystokinin octapeptide and its fragments].
    Author: Molchanova IV, Belokrylov GA, Popova OIa, Kalikhevich VN.
    Journal: Biull Eksp Biol Med; 1992 Dec; 114(12):631-3. PubMed ID: 1292696.
    Abstract:
    Immunostimulating properties of cholecystokinin octapeptide (CCK-8) were evaluated in experiments on adult normal and thymectomized mice, in vitro. It was shown that CCK-8 stimulates IgM-PFC production to SRBC, but does not change the immune response to Vi-antigen. CCK-8 increases the number of Thy-I+ spleen T cells and restores thymus-dependent immune response in thymectomized mice. CCK-8 has no effect on neutrophil phagocytosis activity in vitro. The immunostimulating activity of CCK-8 is related mainly to C-terminal fragment (identical to pentagastrin tetrapeptide) since the N-terminal CCK-8 tetrapeptide displays negligible effect in all tests.
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