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  • Title: Detection of a metallo-beta-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups.
    Author: Kurosaki H, Yasuzawa H, Yamaguchi Y, Jin W, Arakawa Y, Goto M.
    Journal: Org Biomol Chem; 2003 Jan 07; 1(1):17-20. PubMed ID: 12929381.
    Abstract:
    A fluorescent probe for the detection of a metallo-beta-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3- mercaptopropionamide (Dansyl-C2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.
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