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Title: Synthesis and antibacterial activity of 1beta-methyl-2-[5-(N-substituted-2-hydroxy iminoethyl)pyrrolidin-3-ylthio]carbapenem derivatives. Author: Oh CH, Lee SC, Cho JH. Journal: Eur J Med Chem; 2003; 38(7-8):751-8. PubMed ID: 12932906. Abstract: The synthesis of a new series of 1-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular, compounds 12b and 12k showed the most potent antibacterial activity.[Abstract] [Full Text] [Related] [New Search]