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  • Title: Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone).
    Author: Watanabe K, Morinaka Y, Iseki K, Watanabe T, Yuki S, Nishi H.
    Journal: Redox Rep; 2003; 8(3):151-5. PubMed ID: 12935312.
    Abstract:
    This paper describes the discovery of a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), as a potent antioxidant agent against lipid peroxidation. The structure-activity relationship of edaravone indicated that lipophilic substituents were essential to show its lipid peroxidation-inhibitory activity. In vivo studies revealed that edaravone showed brain-protective activity in a transient ischemia model.
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