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  • Title: [Masked Philadelphia chromosome: diagnostic implications in a case of chronic myeloid leukemia presenting in blast crisis].
    Author: Carrasco JL, Hernández García MT, Otero A, Vilar MC, Marsá L, González Brito G, García Miranda JL, Hernández Nieto L.
    Journal: Sangre (Barc); 1992 Oct; 37(5):395-8. PubMed ID: 1293781.
    Abstract:
    We present a female patient with acute non-lymphoblastic leukemia (ANLL) and with haematologic features suggestive of its evolution from chronic myeloid leukaemia (CML), in which a bone marrow karyotype showing a "masked" Philadelphia (Ph) chromosome due to a variant translocation of complex type t(9;9;22)(q32;q34;q11) was found. We comment the peculiarities of this special Ph chromosome as well as the differential diagnostic problems between ANLL Ph(+) and CML with onset in blastic crisis.
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