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  • Title: [Results of a randomized, double blind prospective study of intravesical chemoprophylaxis with 2 drugs: adriamycin and mitomycin; and 2 ways of initiating the instillations: early and late. Effect on recurrence and progression].
    Author: Iborra Juan I, Ricos Torrent JV, Monrós Lliso JL, Dumont Martínez R, Casanova Ramón-Borja J, Solsona Narbón E.
    Journal: Arch Esp Urol; 1992 Dec; 45(10):1001-7. PubMed ID: 1294028.
    Abstract:
    The results of a double blind prospective study comparing the chemoprophylactic effects of adriamycin and mitomycin C and two modes of instillation (early: 6 hours following transurethral resection; late: 7-14 days later) for superficial carcinoma of the bladder are presented herein. Since the minimum follow up is over 5 years, the effects on tumor progression and mortality achieved by each of the 4 arms of the protocol were also evaluated. Concerning tumor recurrence, early instillation of mitomycin and overall early instillation therapy achieved significantly better results (p < 0.01). No differences, however, were observed relative to tumor progression or mortality.
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