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  • Title: [Clinical and laboratory studies on childhood acute leukemia with 11q23 abnormalities].
    Author: He YX, Xue YQ, He J, Zhang XL, Ji ZH, Huang YP, Zhu XM, He HL, Chai YH, Zhu LL.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2003 Jul; 24(7):358-61. PubMed ID: 12941190.
    Abstract:
    OBJECTIVE: To investigate the interrelations among morphology, immunology, cytogenetics and clinical outcome in childhood acute leukemia with 11q23 abnormalities. METHODS: Eighteen patients with 11q23 abnormalities, from 320 childhood acute leukemia patients, were retrospectively analysed for cell morphology, flow cytometry, immunophenotyping, R-banding karyotype as well as clinical features and prognosis. Twenty cases of childhood AL with normal karyotype during the same period were used as control. RESULTS: The incidence of 11q23 abnormalities in our childhood acute leukemia patients was 5.63% including 14 acute lymphoblastic leukemia (ALL) and 4 acute myeloid leukemia (AML). Of 16 cases immunophenotypically tested, 13 expressed lymphoid antigens and 3 CD(34) and other myeloid antigens. Karyotype analysis disclosed the following abnormalities: t(4; 11)(q21; q23) in 6 cases, t(10; 11)(p13; q23) in 3, t(11; 19)(q23; p13) in one and del(11)(q23) in 6. The complete remission rate for these patients with 11q23 abnormalities was comparable to that of the control (72.2% vs 80.0%, P > 0.05), while the mortality rate in the former was significantly higher than that in the latter (61.1% vs 25.0%, P < 0.05). CONCLUSIONS: 11q23 abnormalities were mainly seen in childhood ALL and acute monocytic leukemia with unique prognostic features.
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